Monkeypox virus (MPXV) is a zoonotic orthopoxvirus that causes a disease known as monkeypox. This virus was first isolated from rodents in 1958, but has been reported in humans since 1970.
Human cases have occurred in Africa, Asia, Europe, and North America. In the United States, human infections were first identified in 2003 in California.
The symptoms of monkeypox are similar to those of smallpox, except that they tend to appear later in the course of infection. The incubation period ranges from 2-10 days.